SPAG5

Across TCGA patient cohorts, SPAG5 protein abundance is significantly associated with the RNA expression of many other genes, with 13,090 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPAG5-associated genes across cancer lineages are CDKN3, GINS1, and CENPI. Each is linked with SPAG5 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPAG5-to-partner and partner-to-SPAG5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPAG5 versus CDKN3 in BRCA, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG5→partner) and Y-score (partner→SPAG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDKN3 →	+1.136	+0.669	<.001	<.001	3	6
UCEC	GINS1 →	+1.108	+0.723	<.001	<.001	3	6
LUAD	CENPI →	+1.063	+0.937	<.001	<.001	3	6
UCEC	NCAPG →	+1.080	+0.578	<.001	<.001	3	6
LUAD	FOXM1 →	+1.118	+0.969	<.001	<.001	3	6
UCEC	RAD51AP1 →	+1.111	+0.580	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,090 associations by consensus.

SPAG5 vs CDKN3 — BRCA

Explore this scatter interactively →