SPAG5

Across TCGA patient cohorts, SPAG5 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG5-associated genes across cancer lineages are PDCD4, ERK2, and MEK1. Each is linked with SPAG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAG5-to-partner and partner-to-SPAG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SPAG5-low versus SPAG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG5→partner) and Y-score (partner→SPAG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.466	-1.415	.001	.010	3	3
UCEC	ERK2 →	+0.151	+2.222	.011	.009	3	2
UCEC	MEK1 →	+0.346	+1.893	.002	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.390	-1.630	.005	.003	3	2
UCEC	P-Cadherin →	-0.100	-2.000	.025	.029	3	2
COAD	PCNA →	+0.331	+3.008	.010	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

PDCD4 by SPAG5 expression — UCEC

Explore this box plot interactively →