SPAG5

Across TCGA cell cohorts, SPAG5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,731 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPAG5-associated GO terms across cancer lineages are Regulation of chromosome condensation, Resolution of DNA recombination intermediates, and Double-strand break repair via break-induced replication. Each is linked with SPAG5 in more than 19 cancer types. Because this analysis shows association rather than direction, both SPAG5-to-partner and partner-to-SPAG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome condensation grouped by SPAG5-low versus SPAG5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG5→partner) and Y-score (partner→SPAG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of chromosome condensation →	+0.216	+1.406	.002	<.001	3	20
BONE	Resolution of DNA recombination intermediates →	+0.210	+1.775	.001	.007	3	20
PANCREAS	Double-strand break repair via break-induced replication →	+0.280	+1.370	<.001	<.001	3	20
BONE	DNA replication checkpoint signaling →	+0.262	+1.877	<.001	.002	3	20
OESOPHAGUS	DNA integrity checkpoint signaling →	+0.086	+1.251	.006	.002	3	19
BREAST	Positive regulation of cytokinesis →	+0.150	+1.162	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,731 associations by consensus.

Regulation of chromosome condensation by SPAG5 expression — OESOPHAGUS

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