SPAG5

Across TCGA cell cohorts, SPAG5 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPAG5-associated genes across cancer lineages are APOC3, SERPINA11, and ACOT12. Each is linked with SPAG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG5-to-partner and partner-to-SPAG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOC3 grouped by SPAG5-low versus SPAG5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG5→partner) and Y-score (partner→SPAG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	APOC3 →	+1.067	+4.044	<.001	.009	3	2
LUNG_SCLC	SERPINA11 →	+1.590	+4.044	<.001	.009	3	2
LARGE_INTESTINE	ACOT12 →	+0.049	+2.994	<.001	.006	3	2
BLOOD_Leukemia	GPR119 →	+0.008	+4.247	<.001	.004	3	2
PANCREAS	EDDM3B →	+0.020	+5.614	<.001	.002	3	1
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

APOC3 by SPAG5 expression — LUNG_SCLC

Explore this box plot interactively →