SPAG17

Across TCGA cell cohorts, SPAG17 mutation is significantly associated with the RNA expression of many other genes, with 1,079 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPAG17-associated genes across cancer lineages are CBLIF, GOT1, and NDUFAF4. Each is linked with SPAG17 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAG17-to-partner and partner-to-SPAG17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLIF grouped by SPAG17-low versus SPAG17-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG17→partner) and Y-score (partner→SPAG17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CBLIF →	+0.025	+4.169	<.001	.008	3	3
LARGE_INTESTINE	GOT1 →	+0.540	+2.158	.006	.004	3	3
BLOOD_Leukemia	NDUFAF4 →	+0.625	+2.730	.002	.001	3	3
BLOOD_Leukemia	PRR23A →	+0.027	+3.099	<.001	<.001	3	3
BONE	OR2L8 →	+0.020	+4.169	<.001	.008	3	2
OVARY	NAXE →	+0.775	+3.074	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,079 associations by consensus.

CBLIF by SPAG17 expression — BONE

Explore this box plot interactively →