SPAG17

Across TCGA cell cohorts, SPAG17 mutation is significantly associated with the mutation status of many other genes, with 6,455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPAG17-associated genes across cancer lineages are COL14A1, ZNF532, and RYR1. Each is linked with SPAG17 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPAG17-to-partner and partner-to-SPAG17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL14A1 grouped by SPAG17-low versus SPAG17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG17→partner) and Y-score (partner→SPAG17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COL14A1 →	+2.459	+2.345	<.001	<.001	1	7
LUNG_NSCLC_LUAD	ZNF532 →	+3.478	+3.303	.006	.006	1	6
LARGE_INTESTINE	RYR1 →	+1.971	+4.572	<.001	<.001	1	6
BLOOD_Leukemia	GRIK3 →	+3.364	+2.285	.006	.006	1	6
LARGE_INTESTINE	PCDHA2 →	+2.321	+2.129	<.001	<.001	1	6
LARGE_INTESTINE	NIN →	+2.847	+2.693	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,455 associations by consensus.

COL14A1 by SPAG17 expression — LARGE_INTESTINE

Explore this box plot interactively →