SPAG16

Across TCGA patient cohorts, SPAG16 protein abundance is significantly associated with the RNA expression of many other genes, with 828 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPAG16-associated genes across cancer lineages are SLC25A6, FBXO7, and POLR2C. Each is linked with SPAG16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG16-to-partner and partner-to-SPAG16 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPAG16 versus SLC25A6 in CCRCC, with a Pearson correlation of -0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG16→partner) and Y-score (partner→SPAG16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC25A6 →	-0.941	-0.839	.009	.009	3	2
LUAD	FBXO7 →	-0.307	-1.035	.004	<.001	3	1
LUAD	POLR2C →	-0.585	-1.069	<.001	.005	3	1
LUAD	PLD3 →	-0.650	-0.823	.002	.005	3	1
LUAD	CTBS →	-0.471	-1.100	<.001	<.001	3	1
LUAD	GBP3 →	-1.332	-0.877	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 828 associations by consensus.

SPAG16 vs SLC25A6 — CCRCC

Explore this scatter interactively →