SPAG16

Across TCGA pan-cancer cohorts, SPAG16 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPAG16’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SPAG16 RNA is repressed in tumor relative to normal tissue. In most cancer types SPAG16 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and THCA are the cancer types where SPAG16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPAG16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.787	<.001	11	view →
KIRC	Male	II,III,IV	−0.628	<.001	11	view →
THCA	Male	IV	−0.710	<.001	10	view →
HNSC	All	All	−0.639	<.001	10	view →
UCEC	All	III,IV	−1.644	<.001	6	view →
STAD	All	All	−0.628	.003	6	view →
CHOL	Female	All	+2.353	<.001	5	view →
READ	All	All	−1.231	.001	5	view →
COAD	All	All	−0.551	.001	4	view →
BRCA	Female	All	−0.305	.004	4	view →
LIHC	Male	All	+0.292	.025	3	view →
PAAD	All	All	+0.972	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPAG16–KICH

Open the KICH breakdown →