SPAG16

Across TCGA patient cohorts, SPAG16 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG16-associated genes across cancer lineages are Cyclin-B1, p38-MAPK_pT180_Y182, and Caspase-7-cleavedD198. Each is linked with SPAG16 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPAG16-to-partner and partner-to-SPAG16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SPAG16-low versus SPAG16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG16→partner) and Y-score (partner→SPAG16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.741	+3.906	<.001	<.001	3	4
UCEC	p38-MAPK_pT180_Y182 →	-0.430	-1.662	.002	.010	3	3
UCEC	Caspase-7-cleavedD198 →	+0.582	+2.019	.002	.005	3	3
STAD	PCNA →	+0.327	+3.000	.015	.034	3	2
STAD	PKC-delta_pS664 →	-0.137	-3.321	.030	.010	1	4
STAD	c-Kit →	-0.363	-3.000	.014	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Cyclin-B1 by SPAG16 expression — UCEC

Explore this box plot interactively →