SPAG16

Across TCGA cell cohorts, SPAG16 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPAG16-associated genes across cancer lineages are GHRHR, SLC7A10, and MYL7. Each is linked with SPAG16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG16-to-partner and partner-to-SPAG16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by SPAG16-low versus SPAG16-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG16→partner) and Y-score (partner→SPAG16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GHRHR →	+0.464	+4.705	<.001	.003	3	2
SKIN	SLC7A10 →	+0.390	+4.095	<.001	.009	3	2
LUNG_NSCLC_LUAD	MYL7 →	+0.434	+3.786	<.001	.002	3	2
URINARY_TRACT	MMD2 →	+0.063	+5.087	<.001	.004	3	1
URINARY_TRACT	FGF4 →	+0.006	+5.087	<.001	.004	3	1
BLOOD_Myeloma	KRTAP22-2 →	+0.229	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

GHRHR by SPAG16 expression — BLOOD_Leukemia

Explore this box plot interactively →