SPAG11A

Across TCGA patient cohorts, SPAG11A mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG11A-associated genes across cancer lineages are RNU6-1078P, RNU6-159P, and MIR378D1. Each is linked with SPAG11A in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG11A-to-partner and partner-to-SPAG11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1078P grouped by SPAG11A-low versus SPAG11A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG11A→partner) and Y-score (partner→SPAG11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1078P →	+0.278	+7.954	<.001	.008	3	1
HNSC	RNU6-159P →	+0.274	+7.954	<.001	.008	3	1
HNSC	MIR378D1 →	+0.461	+7.954	<.001	.008	3	1
HNSC	MIR4490 →	+0.328	+7.954	<.001	.008	3	1
UCEC	TEX33 →	+0.161	+4.188	.001	.009	3	1
UCEC	MIR548U →	+0.646	+5.027	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

RNU6-1078P by SPAG11A expression — HNSC

Explore this box plot interactively →