SPAG11A

Across TCGA cell cohorts, SPAG11A mutation is significantly associated with the mutation status of many other genes, with 403 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPAG11A-associated genes across cancer lineages are BACE2, CUX1, and SYN3. Each is linked with SPAG11A in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG11A-to-partner and partner-to-SPAG11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BACE2 grouped by SPAG11A-low versus SPAG11A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG11A→partner) and Y-score (partner→SPAG11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BACE2 →	+2.422	+4.050	.004	.004	1	2
LARGE_INTESTINE	CUX1 →	+2.284	+3.925	.005	.005	1	2
LUNG_SCLC	SYN3 →	+5.066	+4.502	.007	.007	1	2
LUNG_SCLC	CNN3 →	+5.066	+4.502	.007	.007	1	2
LUNG_SCLC	SLC17A1 →	+5.066	+4.502	.007	.007	1	2
LUNG_SCLC	ERGIC3 →	+5.066	+4.502	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 403 associations by consensus.

BACE2 by SPAG11A expression — LARGE_INTESTINE

Explore this box plot interactively →