SPAG1

Across TCGA patient cohorts, SPAG1 protein abundance is significantly associated with the protein abundance of many other proteins, with 16,586 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPAG1-associated proteins across cancer lineages are SPAG1_S418, SPAG1_S423, and WDR11. Each is linked with SPAG1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPAG1-to-partner and partner-to-SPAG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPAG1 versus SPAG1_S418 in BRCA, with a Pearson correlation of 0.85.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG1→partner) and Y-score (partner→SPAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPAG1_S418 →	+1.475	+0.780	<.001	<.001	3	9
GBM	SPAG1_S423 →	+1.208	+0.805	<.001	<.001	3	9
GBM	WDR11 →	+0.189	+0.420	<.001	<.001	3	5
BRCA	ARFGEF1 →	+0.369	+0.400	<.001	<.001	3	5
GBM	ARHGEF2 →	-0.317	-0.579	<.001	<.001	3	5
LUAD	SPAG1_S791 →	+0.893	+0.651	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,586 associations by consensus.

SPAG1 vs SPAG1_S418 — BRCA

Explore this scatter interactively →