SPAG1

Across TCGA pan-cancer cohorts, SPAG1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SPAG1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SPAG1 RNA is repressed in tumor relative to normal tissue. In most cancer types SPAG1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, KIRC, and BRCA are the cancer types where SPAG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPAG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.405	<.001	8	view →
KIRC	All	All	+0.346	.001	8	view →
BRCA	All	III,IV	+1.228	<.001	6	view →
THCA	Female	All	−0.510	<.001	6	view →
STAD	All	All	+0.859	.001	5	view →
CHOL	All	All	+1.786	<.001	3	view →
LUSC	Female	II,III,IV	−0.918	.028	3	view →
LIHC	All	All	+0.507	<.001	3	view →
PAAD	All	All	+0.702	.015	2	view →
BLCA	Male	III,IV	+1.018	.037	1	view →
LUAD	All	II,III,IV	+0.493	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SPAG1–KICH

Open the KICH breakdown →