SPAG1

Across TCGA patient cohorts, SPAG1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG1-associated genes across cancer lineages are FoxM1, NF2, and p62 Lck ligand. Each is linked with SPAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG1-to-partner and partner-to-SPAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SPAG1-low versus SPAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG1→partner) and Y-score (partner→SPAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.279	+2.169	.004	.003	3	2
UCEC	NF2 →	+0.228	+2.584	.004	.010	3	2
UCEC	p62 Lck ligand →	+0.369	+3.710	.002	<.001	3	2
UCEC	PRAS40_pT246 →	+0.191	+2.115	.003	.017	3	2
UCEC	Annexin_VII →	-0.125	-1.765	.016	.014	3	2
UCEC	BRD4 →	+0.219	+3.169	.029	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

FoxM1 by SPAG1 expression — UCEC

Explore this box plot interactively →