SPAG1

Across TCGA cell cohorts, SPAG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,351 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPAG1-associated GO terms across cancer lineages are Vesicle-mediated transport to the plasma membrane, Endosomal transport, and Membrane fission. Each is linked with SPAG1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SPAG1-to-partner and partner-to-SPAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle-mediated transport to the plasma membrane grouped by SPAG1-low versus SPAG1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG1→partner) and Y-score (partner→SPAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Vesicle-mediated transport to the plasma membrane →	+0.070	+1.539	<.001	<.001	3	10
LUNG_SCLC	Endosomal transport →	+0.071	+1.434	<.001	<.001	3	10
BLOOD_Lymphoma	Membrane fission →	+0.042	+1.504	<.001	<.001	3	10
OVARY	Septin cytoskeleton organization →	+0.117	+1.021	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol dephosphorylation →	+0.063	+0.995	.003	.002	3	9
OESOPHAGUS	Septin ring organization →	+0.137	+0.905	.002	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,351 associations by consensus.

Vesicle-mediated transport to the plasma membrane by SPAG1 expression — LUNG_SCLC

Explore this box plot interactively →