SPAG1

Across TCGA cell cohorts, SPAG1 mutation is significantly associated with the RNA expression of many other genes, with 238 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPAG1-associated genes across cancer lineages are FUT10, BPIFA1, and CBY1. Each is linked with SPAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG1-to-partner and partner-to-SPAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FUT10 grouped by SPAG1-low versus SPAG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG1→partner) and Y-score (partner→SPAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FUT10 →	+0.724	+3.169	.002	.009	3	2
LARGE_INTESTINE	BPIFA1 →	+0.103	+2.202	<.001	.006	3	2
LARGE_INTESTINE	CBY1 →	+0.746	+2.451	<.001	.009	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.644	+3.502	<.001	.001	3	1
LARGE_INTESTINE	CNIH1 →	+0.461	+2.451	.004	.009	3	1
LARGE_INTESTINE	DNAJA3 →	+0.507	+2.451	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 238 associations by consensus.

FUT10 by SPAG1 expression — LARGE_INTESTINE

Explore this box plot interactively →