SPACA7

Across TCGA patient cohorts, SPACA7 mutation is significantly associated with the RNA expression of many other genes, with 1,279 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA7-associated genes across cancer lineages are TMEM37, SART3, and METTL2A. Each is linked with SPACA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA7-to-partner and partner-to-SPACA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM37 grouped by SPACA7-low versus SPACA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA7→partner) and Y-score (partner→SPACA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM37 →	-1.128	-3.574	.005	.003	3	2
UCEC	SART3 →	+0.552	+3.332	.002	.005	3	2
UCEC	METTL2A →	+0.539	+3.595	.002	.001	3	2
UCEC	KHSRP →	+0.636	+3.370	<.001	.004	3	2
UCEC	NUP50 →	+0.700	+3.584	<.001	.003	3	2
UCEC	BRF2 →	+0.706	+3.329	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,279 associations by consensus.

TMEM37 by SPACA7 expression — UCEC

Explore this box plot interactively →