SPACA7

Across TCGA pan-cancer cohorts, SPACA7 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SPACA7 data layer compared with 6 for mutation status.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher SPACA7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPACA7 expression acts as an unfavorable survival marker, although some lineages such as CESC and SARC show a favorable association.

READ, BRCA, and CHOL are the cancer types where SPACA7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	All	0.242	0.710	<.001	42	view →
BRCA	DFS	Tertile	All	0.140	1.000	.001	39	view →
CHOL	OS	Tertile	III,IV	0.024	0.772	.008	36	view →
CESC	OS	Tertile	All	0.957	0.771	.008	30	view →
LGG	DFS	Tertile	All	0.253	0.416	.002	30	view →
THCA	OS	Median	All	0.839	1.000	.009	22	view →
TGCT	OS	Tertile	III,IV	0.501	1.000	.014	20	view →
UCS	DFS	Tertile	IV	0.318	0.745	.042	18	view →
KICH	OS	Tertile	All	0.601	0.901	.012	9	view →
GBM	DFS	Tertile	All	0.090	0.249	.005	9	view →
STAD	DFS	Tertile	III,IV	0.244	0.508	.045	6	view →
SARC	DFS	Tertile	All	0.680	0.480	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SPACA7–READ (DFS)

Open the READ breakdown →