SPACA7

Across TCGA patient cohorts, SPACA7 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPACA7-associated genes across cancer lineages are Notch1, Akt_pS473, and Akt_pT308. Each is linked with SPACA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA7-to-partner and partner-to-SPACA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SPACA7-low versus SPACA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA7→partner) and Y-score (partner→SPACA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.186	+3.169	.016	.020	3	1
SKCM	Akt_pS473 →	+0.853	+2.824	.009	.034	3	1
SKCM	Akt_pT308 →	+0.888	+2.820	.003	.035	3	1
SKCM	4E-BP1_pT70 →	+0.250	+2.824	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Notch1 by SPACA7 expression — UCEC

Explore this box plot interactively →