SPACA6P-AS

Across TCGA pan-cancer cohorts, SPACA6P-AS RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SPACA6P-AS data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SPACA6P-AS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPACA6P-AS expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

KIRC, KIRP, and BRCA are the cancer types where SPACA6P-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.500	0.707	<.001	125	view →
KIRP	OS	Tertile	II,III,IV	0.276	1.000	.002	67	view →
BRCA	OS	Quartile	II,III,IV	0.490	0.685	.003	41	view →
LUSC	DFS	Median	III,IV	0.199	0.465	.004	34	view →
UVM	DFS	Median	III,IV	0.267	0.796	.002	34	view →
LGG	DFS	Quartile	All	0.629	0.817	<.001	30	view →
UCEC	DFS	Tertile	All	0.517	0.701	.006	26	view →
LIHC	OS	Tertile	II,III,IV	0.223	0.596	<.001	25	view →
CESC	DFS	Tertile	All	0.742	0.854	.005	18	view →
MESO	DFS	Quartile	All	0.250	0.679	.026	15	view →
CHOL	DFS	Median	II,III,IV	0.108	0.509	.012	12	view →
KICH	DFS	Quartile	III,IV	0.290	0.913	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SPACA6P-AS–KIRC (DFS)

Open the KIRC breakdown →