SPACA3

Across TCGA patient cohorts, SPACA3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA3-associated genes across cancer lineages are p62 Lck ligand, Annexin-1, and AMPK_alpha. Each is linked with SPACA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA3-to-partner and partner-to-SPACA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SPACA3-low versus SPACA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA3→partner) and Y-score (partner→SPACA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.390	+2.415	.002	.003	3	2
UCEC	Annexin-1 →	+0.633	+2.415	.002	.003	3	2
SKCM	AMPK_alpha →	+0.196	+3.000	.010	.035	3	1
UCEC	eEF2 →	+0.374	+1.874	.009	.049	3	1
UCEC	EGFR_pY1068 →	-0.214	-2.459	.034	.019	3	1
UCEC	ERK2 →	+0.213	+2.700	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

p62 Lck ligand by SPACA3 expression — UCEC

Explore this box plot interactively →