SPACA3

Across TCGA cell cohorts, SPACA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,142 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPACA3-associated GO terms across cancer lineages are Left ventricular cardiac muscle tissue morphogenesis, L-tryptophan metabolic process, and G1 to G0 transition involved in cell differentiation. Each is linked with SPACA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPACA3-to-partner and partner-to-SPACA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Left ventricular cardiac muscle tissue morphogenesis grouped by SPACA3-low versus SPACA3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA3→partner) and Y-score (partner→SPACA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Left ventricular cardiac muscle tissue morphogenesis →	-0.189	-0.433	.005	.001	3	4
BONE	L-tryptophan metabolic process →	+0.156	+0.413	.004	.004	3	4
SKIN	G1 to G0 transition involved in cell differentiation →	+1.076	+0.639	<.001	<.001	3	4
SKIN	Extracellular exosome biogenesis →	+0.175	+0.601	<.001	<.001	3	4
BONE	Regulation of small intestine smooth muscle contraction →	+1.654	+0.523	<.001	.001	3	4
BONE	Positive regulation of small intestine smooth muscle contraction →	+1.654	+0.523	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,142 associations by consensus.

Left ventricular cardiac muscle tissue morphogenesis by SPACA3 expression — BLOOD_Lymphoma

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