SPACA1

Across TCGA patient cohorts, SPACA1 mutation is significantly associated with the RNA expression of many other genes, with 2,532 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA1-associated genes across cancer lineages are MLLT10, NOA1, and CWF19L1. Each is linked with SPACA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPACA1-to-partner and partner-to-SPACA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLLT10 grouped by SPACA1-low versus SPACA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA1→partner) and Y-score (partner→SPACA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MLLT10 →	+0.440	+2.609	.004	.006	3	3
UCEC	NOA1 →	+0.530	+3.343	<.001	<.001	3	3
UCEC	CWF19L1 →	+0.395	+2.191	.001	.002	3	3
UCEC	RBSN →	+0.424	+3.080	.001	<.001	3	3
LUAD	MIR7845 →	+0.578	+4.345	<.001	.007	3	2
UCEC	DCP1A →	+0.547	+2.439	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,532 associations by consensus.

MLLT10 by SPACA1 expression — UCEC

Explore this box plot interactively →