SPACA1

Across TCGA patient cohorts, SPACA1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA1-associated genes across cancer lineages are JNK2, p62 Lck ligand, and 14-3-3_beta. Each is linked with SPACA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA1-to-partner and partner-to-SPACA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SPACA1-low versus SPACA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA1→partner) and Y-score (partner→SPACA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.193	+3.348	.013	.004	3	2
UCEC	p62 Lck ligand →	+0.310	+3.169	.015	.018	3	2
UCEC	14-3-3_beta →	-0.092	-1.986	.019	.010	3	1
UCEC	EGFR →	-0.132	-1.584	.035	.036	3	1
UCEC	FoxM1 →	+0.221	+2.502	.029	.002	3	1
UCEC	Heregulin →	-0.117	-2.700	.015	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

JNK2 by SPACA1 expression — UCEC

Explore this box plot interactively →