SPACA1

Across TCGA cell cohorts, SPACA1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SPACA1-associated genes across cancer lineages are DYNAP, PRAMEF2, and COX6A2. Each is linked with SPACA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA1-to-partner and partner-to-SPACA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYNAP grouped by SPACA1-low versus SPACA1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA1→partner) and Y-score (partner→SPACA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DYNAP →	+0.167	+4.070	.003	.003	3	2
LUNG_SCLC	PRAMEF2 →	+0.019	+4.169	<.001	.001	3	1
LUNG_SCLC	COX6A2 →	+0.414	+4.256	<.001	.002	3	1
LUNG_SCLC	MBD3L1 →	+0.036	+4.058	<.001	.007	3	1
LUNG_SCLC	TRIM49B →	+0.506	+3.898	.001	.005	3	1
LUNG_SCLC	IFIT1B →	+0.025	+3.898	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

DYNAP by SPACA1 expression — LUNG_SCLC

Explore this box plot interactively →