SPA17

Across TCGA cell cohorts, SPA17 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,576 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPA17-associated GO terms across cancer lineages are Intraciliary anterograde transport, Intraciliary transport involved in cilium assembly, and Protein localization to cilium. Each is linked with SPA17 in more than 9 cancer types. Because this analysis shows association rather than direction, both SPA17-to-partner and partner-to-SPA17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intraciliary anterograde transport grouped by SPA17-low versus SPA17-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPA17→partner) and Y-score (partner→SPA17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Intraciliary anterograde transport →	+0.116	+2.065	.001	<.001	3	10
LUNG_SCLC	Intraciliary transport involved in cilium assembly →	+0.117	+1.240	.003	.008	3	10
LIVER	Protein localization to cilium →	+0.065	+1.089	.005	.003	3	10
CNS	Regulation of sister chromatid segregation →	+0.054	+0.625	<.001	<.001	3	9
CNS	Regulation of chromosome separation →	+0.094	+0.568	<.001	.001	3	8
LUNG_NSCLC_LUAD	Negative regulation of nuclear division →	+0.104	+0.995	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,576 associations by consensus.

Intraciliary anterograde transport by SPA17 expression — LUNG_SCLC

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