SPA17

Across TCGA pan-cancer cohorts, SPA17 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SPA17 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher SPA17 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPA17 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

KICH, LIHC, and KIRC are the cancer types where SPA17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.835	1.000	<.001	106	view →
LIHC	DFS	Median	All	0.449	0.634	<.001	80	view →
KIRC	DFS	Median	All	0.717	0.527	<.001	57	view →
UCEC	DFS	Median	All	0.712	0.581	<.001	52	view →
LGG	OS	Median	All	0.712	0.922	<.001	52	view →
KIRP	DFS	Median	All	0.901	0.600	.002	41	view →
BLCA	DFS	Tertile	IV	0.252	0.631	.001	39	view →
BRCA	DFS	Median	All	0.575	0.451	.001	36	view →
DLBC	DFS	Median	All	0.959	0.670	.002	31	view →
ACC	OS	Tertile	All	0.731	0.934	.003	23	view →
COAD	OS	Median	All	0.643	0.535	.011	20	view →
LUAD	OS	Median	III,IV	0.513	0.790	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SPA17–KICH (OS)

Open the KICH breakdown →