SP8

Across TCGA patient cohorts, SP8 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,072 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible SP8-associated GO terms across cancer lineages are Nuclear membrane organization, Nuclear envelope organization, and Establishment of mitotic spindle localization. Each is linked with SP8 in more than 17 cancer types. Because this analysis shows association rather than direction, both SP8-to-partner and partner-to-SP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear membrane organization grouped by SP8-low versus SP8-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SP8→partner) and Y-score (partner→SP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Nuclear membrane organization →	+0.058	+0.401	<.001	<.001	3	18
STAD	Nuclear envelope organization →	+0.062	+0.391	<.001	<.001	3	16
SCLC	Establishment of mitotic spindle localization →	+0.097	+1.734	.001	.001	2	17
STAD	Maintenance of cell number →	+0.050	+0.349	<.001	<.001	3	15
STAD	Microtubule cytoskeleton organization involved in mitosis →	+0.073	+0.438	<.001	<.001	3	15
STAD	Positive regulation of cell cycle process →	+0.060	+0.434	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,072 associations by consensus.

Nuclear membrane organization by SP8 expression — STAD

Explore this box plot interactively →