SP8

Across TCGA pan-cancer cohorts, SP8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SP8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SP8 is over-expressed in tumor.

THCA, LUAD, and COAD are the cancer types where SP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	+0.019	.002	9	view →
LUAD	All	II,III,IV	+1.125	<.001	8	view →
COAD	All	All	+0.665	<.001	8	view →
HNSC	Male	All	+0.650	<.001	8	view →
STAD	All	All	+0.428	.002	6	view →
LUSC	All	II,III,IV	+0.871	<.001	5	view →
UCEC	All	All	+1.149	<.001	4	view →
LIHC	All	All	+0.183	.006	3	view →
READ	Female	All	+0.522	.004	2	view →
BRCA	All	II,III,IV	+0.010	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SP8–THCA

Open the THCA breakdown →