SP8

Across TCGA patient cohorts, SP8 mutation is significantly associated with the RNA expression of many other genes, with 4,822 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP8-associated genes across cancer lineages are RNU6-898P, RNU1-57P, and RNU4-59P. Each is linked with SP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SP8-to-partner and partner-to-SP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-898P grouped by SP8-low versus SP8-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP8→partner) and Y-score (partner→SP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-898P →	+0.517	+5.106	<.001	.008	3	3
COAD	RNU1-57P →	+1.303	+3.730	<.001	.004	3	3
COAD	RNU4-59P →	+0.975	+4.375	<.001	.001	3	3
COAD	RNU6-164P →	+0.504	+4.821	<.001	.003	3	3
COAD	RNA5SP86 →	+0.829	+4.821	<.001	.003	3	3
ESCA	RNA5SP64 →	+0.281	+4.450	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,822 associations by consensus.

RNU6-898P by SP8 expression — BLCA

Explore this box plot interactively →