SP8

Across TCGA cell cohorts, SP8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,818 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SP8-associated GO terms across cancer lineages are RNA methylation, Renal filtration, and Aminoacyl-tRNA metabolism involved in translational fidelity. Each is linked with SP8 in more than 5 cancer types. Because this analysis shows association rather than direction, both SP8-to-partner and partner-to-SP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA methylation grouped by SP8-low versus SP8-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SP8→partner) and Y-score (partner→SP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RNA methylation →	+0.066	+1.693	.002	.004	3	6
LUNG_NSCLC_LUSC	Renal filtration →	-0.195	-1.028	<.001	.003	3	6
LIVER	Aminoacyl-tRNA metabolism involved in translational fidelity →	+0.074	+1.250	.006	.009	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription elongation by RNA polymerase II →	+0.042	+0.201	.007	.007	3	6
BLOOD_Lymphoma	Beige fat cell differentiation →	-0.130	-0.126	<.001	.008	3	5
BLOOD_Lymphoma	Protein localization to nuclear envelope →	+0.068	+0.150	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,818 associations by consensus.

RNA methylation by SP8 expression — LIVER

Explore this box plot interactively →