SP8

Across TCGA cell cohorts, SP8 mutation is significantly associated with the RNA expression of many other genes, with 399 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SP8-associated genes across cancer lineages are CRYBB1, OR1L6, and C2orf80. Each is linked with SP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP8-to-partner and partner-to-SP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB1 grouped by SP8-low versus SP8-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP8→partner) and Y-score (partner→SP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CRYBB1 →	+0.026	+4.906	<.001	.006	3	1
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
BLOOD_Lymphoma	OR2AJ1 →	+0.042	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR6J1 →	+0.006	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 399 associations by consensus.

CRYBB1 by SP8 expression — OESOPHAGUS

Explore this box plot interactively →