SP7

Across TCGA patient cohorts, SP7 mutation is significantly associated with the RNA expression of many other genes, with 1,070 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP7-associated genes across cancer lineages are HSPE1P21, RNU6-247P, and RNU6-893P. Each is linked with SP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP7-to-partner and partner-to-SP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPE1P21 grouped by SP7-low versus SP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP7→partner) and Y-score (partner→SP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPE1P21 →	+0.228	+2.541	<.001	<.001	3	2
BLCA	RNU6-247P →	+0.771	+4.069	<.001	.002	3	2
BLCA	RNU6-893P →	+0.438	+3.343	.001	.007	3	2
SKCM	RPL36AP41 →	+0.145	+2.666	.002	.003	3	2
LUAD	LHX5-AS1 →	+1.624	+4.962	<.001	.002	3	2
UCEC	LINC01072 →	+0.143	+2.488	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,070 associations by consensus.

HSPE1P21 by SP7 expression — UCEC

Explore this box plot interactively →