SP2

Across TCGA patient cohorts, SP2 mutation is significantly associated with the RNA expression of many other genes, with 2,955 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP2-associated genes across cancer lineages are RNU4-87P, MIR3169, and MIR548AE1. Each is linked with SP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP2-to-partner and partner-to-SP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-87P grouped by SP2-low versus SP2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP2→partner) and Y-score (partner→SP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU4-87P →	+0.363	+4.743	<.001	.005	3	2
HNSC	MIR3169 →	+0.347	+7.954	<.001	.008	3	2
HNSC	MIR548AE1 →	+0.395	+7.954	<.001	.008	3	2
HNSC	MIR1264 →	+0.273	+7.954	<.001	.008	3	2
PRAD	RNU7-46P →	+0.503	+7.939	<.001	.008	3	2
COAD	TRAJ12 →	+1.152	+3.140	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,955 associations by consensus.

RNU4-87P by SP2 expression — SKCM

Explore this box plot interactively →