SP2-AS1

Across TCGA pan-cancer cohorts, SP2-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SP2-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SP2-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SP2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

UCS, KICH, and KIRC are the cancer types where SP2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Quartile	II,III,IV	0.651	0.143	.007	48	view →
KICH	DFS	Tertile	All	0.624	1.000	<.001	43	view →
KIRC	DFS	Tertile	All	0.869	0.731	.003	40	view →
LGG	DFS	Median	All	0.479	0.275	<.001	39	view →
SKCM	OS	Median	All	0.378	0.261	.003	34	view →
PAAD	DFS	Median	II,III,IV	0.372	0.524	.004	32	view →
KIRP	DFS	Median	IV	0.036	0.526	.006	30	view →
BLCA	OS	Quartile	All	0.513	0.816	.001	26	view →
LUAD	DFS	Median	IV	0.745	0.254	.010	22	view →
HNSC	DFS	Tertile	IV	0.712	0.532	.012	14	view →
ACC	DFS	Tertile	II,III,IV	0.349	0.701	.004	13	view →
THCA	OS	Quartile	II,III,IV	0.709	0.958	.016	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SP2-AS1–UCS (DFS)

Open the UCS breakdown →