Q-omics provides the consensus-scored SP2-AS1 profile across patient tissues and cancer cell-line models. SP2-AS1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, SP2-AS1 is differentially expressed in 14, with the highest sampling consensus in KIRP. Additionally, SP2-AS1 RNA expression shows 20,559 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UCS, KIRP, and ACC as cancer lineages where SP2-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SP2-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SP2-AS1 survival associations across molecular data types. SP2-AS1 RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SP2-AS1 RNA expression–survival associations across cancer types. High SP2-AS1 expression shows unfavorable associations in KICH and PAAD, but favorable associations in UCS, KIRC, LGG and SKCM. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .007). Together, the overview and detailed table identify UCS as the clearest survival context for SP2-AS1 RNA expression.
This table summarizes SP2-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for SP2-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SP2-AS1 shows lower tumor expression in THCA and KICH and higher tumor expression in KIRP, LUAD, COAD and KIRC. The KIRP box plot shows higher SP2-AS1 RNA expression in tumor versus normal tissue (log2 FC = +1.454, t-test p < 0.001).
This table shows molecular features associated with SP2-AS1 in patient tissues and cancer cell lines. In patient samples, SP2-AS1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
