SP140

Across TCGA patient cohorts, SP140 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,530 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SP140-associated proteins across cancer lineages are ADA2, BTK, and CASP1. Each is linked with SP140 in more than 9 cancer types. Because this analysis shows association rather than direction, both SP140-to-partner and partner-to-SP140 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SP140 versus ADA2 in LSCC, with a Pearson correlation of 0.77.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140→partner) and Y-score (partner→SP140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADA2 →	+0.664	+1.094	<.001	<.001	3	10
LSCC	BTK →	+0.693	+1.175	<.001	<.001	3	10
OV	CASP1 →	+0.711	+0.928	<.001	<.001	3	10
LSCC	CCDC88B_S597 →	+0.964	+1.210	<.001	<.001	3	10
BRCA	CD38 →	+1.116	+0.924	<.001	<.001	3	10
LSCC	CD4 →	+0.792	+1.209	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,530 associations by consensus.

SP140 vs ADA2 — LSCC

Explore this scatter interactively →