SP140

Across TCGA pan-cancer cohorts, SP140 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SP140 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SP140 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SP140 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and CESC are the cancer types where SP140 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.441	0.247	<.001	129	view →
HNSC	DFS	Tertile	All	0.791	0.645	<.001	122	view →
CESC	DFS	Median	All	0.889	0.749	<.001	72	view →
KIRP	DFS	Quartile	All	0.300	0.743	<.001	70	view →
UVM	DFS	Median	II,III,IV	0.421	0.713	.001	60	view →
LGG	DFS	Median	All	0.289	0.491	<.001	53	view →
KIRC	OS	Quartile	All	0.552	0.760	.002	50	view →
OV	DFS	Tertile	All	0.240	0.121	.003	42	view →
THYM	DFS	Median	II,III,IV	0.655	1.000	<.001	36	view →
LUAD	DFS	Tertile	All	0.733	0.606	.004	19	view →
ACC	OS	Median	IV	0.309	0.777	.019	13	view →
STAD	DFS	Tertile	II,III,IV	0.723	0.472	.028	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SP140–SKCM (OS)

Open the SKCM breakdown →