SP140

Across TCGA patient cohorts, SP140 protein abundance is significantly associated with the protein abundance of many other proteins, with 14,388 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SP140-associated proteins across cancer lineages are RASAL3_S988, THEMIS2, and ANKRD44. Each is linked with SP140 in more than 5 cancer types. Because this analysis shows association rather than direction, both SP140-to-partner and partner-to-SP140 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SP140 versus RASAL3_S988 in UCEC, with a Pearson correlation of 0.83.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140→partner) and Y-score (partner→SP140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RASAL3_S988 →	+1.465	+0.906	.001	.002	3	6
UCEC	THEMIS2 →	+1.271	+0.766	<.001	<.001	3	6
UCEC	ANKRD44 →	+1.075	+0.787	<.001	<.001	3	6
UCEC	BIN2_S458 →	+1.050	+0.553	.003	<.001	3	6
UCEC	ADA2 →	+1.444	+0.804	<.001	<.001	3	6
UCEC	CCDC88B_S597 →	+1.006	+0.536	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,388 associations by consensus.

SP140 vs RASAL3_S988 — UCEC

Explore this scatter interactively →