SP140

Across TCGA patient cohorts, SP140 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP140-associated genes across cancer lineages are 4E-BP1, STAT3_pY705, and Cyclin-B1. Each is linked with SP140 in more than 3 cancer types. Because this analysis shows association rather than direction, both SP140-to-partner and partner-to-SP140 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SP140-low versus SP140-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140→partner) and Y-score (partner→SP140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.284	+2.700	.002	.005	3	4
UCEC	STAT3_pY705 →	-0.321	-1.584	<.001	.032	3	3
UCEC	Cyclin-B1 →	+0.527	+3.459	.005	.005	3	3
SKCM	p21 →	-0.280	-1.584	.026	.030	3	2
SKCM	Rad50 →	-0.168	-1.700	.047	.038	3	2
UCEC	Caspase-8 →	-0.185	-1.673	.031	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

4E-BP1 by SP140 expression — UCEC

Explore this box plot interactively →