SP140

Across TCGA cell cohorts, SP140 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,799 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SP140-associated GO terms across cancer lineages are Peptide antigen transport, Cytoplasmic pattern recognition receptor signaling pathway, and Hepatocyte growth factor receptor signaling pathway. Each is linked with SP140 in more than 11 cancer types. Because this analysis shows association rather than direction, both SP140-to-partner and partner-to-SP140 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptide antigen transport grouped by SP140-low versus SP140-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140→partner) and Y-score (partner→SP140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Peptide antigen transport →	+1.218	+1.312	<.001	<.001	3	12
BLOOD_Lymphoma	Cytoplasmic pattern recognition receptor signaling pathway →	+0.080	+1.631	<.001	<.001	3	11
LIVER	Hepatocyte growth factor receptor signaling pathway →	+0.204	+2.085	.005	.007	3	11
BONE	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.152	+0.982	.001	.005	3	10
BREAST	Negative regulation of immune response →	+0.071	+0.404	.002	.003	3	10
SOFT_TISSUE	Antigen processing and presentation via MHC class Ib →	+0.250	+0.969	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,799 associations by consensus.

Peptide antigen transport by SP140 expression — BONE

Explore this box plot interactively →