SP140

Across TCGA cell cohorts, SP140 mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SP140-associated genes across cancer lineages are MPL, FAM162B, and AKAP4. Each is linked with SP140 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP140-to-partner and partner-to-SP140 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPL grouped by SP140-low versus SP140-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140→partner) and Y-score (partner→SP140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MPL →	+0.100	+2.588	.006	.004	3	2
LUNG_SCLC	FAM162B →	+0.984	+3.669	<.001	.004	3	1
LUNG_NSCLC_LUAD	AKAP4 →	+0.010	+3.544	.001	.009	3	1
LUNG_NSCLC_LUAD	FAM47A →	+0.062	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	MT1H →	+1.618	+3.866	<.001	.006	3	1
LUNG_NSCLC_LUAD	MT1HL1 →	+0.104	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

MPL by SP140 expression — LARGE_INTESTINE

Explore this box plot interactively →