SP100

Across TCGA cell cohorts, SP100 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SP100-associated genes across cancer lineages are WFDC11, OXT, and IQSEC3. Each is linked with SP100 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP100-to-partner and partner-to-SP100 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC11 grouped by SP100-low versus SP100-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP100→partner) and Y-score (partner→SP100) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	WFDC11 →	+0.053	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUAD	OXT →	+0.303	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	IQSEC3 →	+0.106	+3.605	.001	.007	3	1
LUNG_NSCLC_LUAD	TEX28 →	+0.004	+4.228	<.001	<.001	3	1
LUNG_NSCLC_LUAD	DNAAF6 →	+0.031	+3.518	.001	.008	3	1
LUNG_SCLC	TAAR5 →	+0.016	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

WFDC11 by SP100 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →