SOX9-AS1

Across TCGA pan-cancer cohorts, SOX9-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SOX9-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SOX9-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SOX9-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

KIRP, LGG, and UCEC are the cancer types where SOX9-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.921	0.496	<.001	93	view →
LGG	OS	Median	All	0.855	0.929	<.001	41	view →
UCEC	DFS	Tertile	II,III,IV	0.634	0.804	.010	38	view →
CESC	DFS	Tertile	All	0.769	0.898	.001	34	view →
KIRC	OS	Median	All	0.703	0.555	<.001	33	view →
SARC	DFS	Tertile	All	0.264	0.543	.003	16	view →
DLBC	OS	Quartile	II,III,IV	0.257	1.000	.012	16	view →
THCA	DFS	Median	IV	0.485	0.787	.018	14	view →
HNSC	DFS	Median	IV	0.660	0.505	.006	13	view →
STAD	OS	Quartile	III,IV	0.641	0.324	.020	11	view →
THYM	OS	Median	II,III,IV	0.878	1.000	.005	10	view →
COAD	OS	Median	III,IV	0.332	0.754	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SOX9-AS1–KIRP (DFS)

Open the KIRP breakdown →