SOX9-AS1

Across TCGA pan-cancer cohorts, SOX9-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SOX9-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SOX9-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SOX9-AS1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, LIHC, and COAD are the cancer types where SOX9-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX9-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.751	<.001	9	view →
LIHC	Female	II,III,IV	+0.729	<.001	9	view →
COAD	All	All	+0.263	<.001	7	view →
BRCA	All	III,IV	−1.738	<.001	6	view →
HNSC	All	II,III,IV	−0.387	<.001	6	view →
KIRC	All	All	+0.235	.001	5	view →
CHOL	All	All	+1.546	<.001	3	view →
KICH	All	All	−0.422	.001	3	view →
STAD	All	All	+0.205	.002	3	view →
LUAD	Female	III,IV	−0.138	.011	3	view →
READ	Female	All	+0.765	.005	2	view →
KIRP	Male	All	+0.328	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SOX9-AS1–THCA

Open the THCA breakdown →