SOX8

Across TCGA patient cohorts, SOX8 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX8-associated genes across cancer lineages are Pericytes, Macrophages M2, and aDC. Each is linked with SOX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX8-to-partner and partner-to-SOX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pericytes grouped by SOX8-low versus SOX8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX8→partner) and Y-score (partner→SOX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Pericytes →	+0.037	+2.651	<.001	.036	3	1
UCEC	Macrophages M2 →	+0.013	+3.118	.027	.016	3	1
UCEC	aDC →	+0.113	+2.815	.008	.036	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Pericytes by SOX8 expression — LUSC

Explore this box plot interactively →