SOX8

Across TCGA pan-cancer cohorts, SOX8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SOX8’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SOX8 RNA is repressed in tumor relative to normal tissue. In most cancer types SOX8 is over-expressed in tumor, although a few such as BLCA and BRCA show the opposite, repressed pattern.

BLCA, THCA, and KIRP are the cancer types where SOX8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−0.811	<.001	12	view →
THCA	Male	All	+1.008	<.001	9	view →
KIRP	All	III,IV	+1.820	<.001	7	view →
BRCA	All	III,IV	−1.313	<.001	6	view →
STAD	All	All	+0.800	.035	4	view →
CHOL	All	II,III,IV	+4.914	.004	3	view →
HNSC	All	All	−0.286	.028	3	view →
KIRC	Male	II,III,IV	−0.199	.005	3	view →
LIHC	All	II,III,IV	+0.087	.023	3	view →
UCEC	All	All	−0.466	.027	2	view →
LUSC	Female	All	−0.423	.020	2	view →
PRAD	All	All	+0.372	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SOX8–BLCA

Open the BLCA breakdown →