SOX8

Across TCGA cell cohorts, SOX8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,539 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SOX8-associated GO terms across cancer lineages are Primary alcohol biosynthetic process, Aldosterone metabolic process, and Aldosterone biosynthetic process. Each is linked with SOX8 in more than 8 cancer types. Because this analysis shows association rather than direction, both SOX8-to-partner and partner-to-SOX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Primary alcohol biosynthetic process grouped by SOX8-low versus SOX8-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX8→partner) and Y-score (partner→SOX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Primary alcohol biosynthetic process →	-0.211	-2.063	<.001	<.001	3	9
BONE	Aldosterone metabolic process →	+1.779	+1.733	<.001	.001	3	8
BONE	Aldosterone biosynthetic process →	+1.990	+1.847	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Calcium ion transport →	-0.043	-0.287	.001	.006	3	8
SOFT_TISSUE	Protein-DNA complex organization →	+0.047	+2.406	<.001	<.001	3	8
BONE	Mineralocorticoid metabolic process →	+1.864	+1.760	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,539 associations by consensus.

Primary alcohol biosynthetic process by SOX8 expression — SOFT_TISSUE

Explore this box plot interactively →