SOX8

Across TCGA cell cohorts, SOX8 mutation is significantly associated with the RNA expression of many other genes, with 237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX8-associated genes across cancer lineages are IFNA8, OR2W1, and GPHA2. Each is linked with SOX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX8-to-partner and partner-to-SOX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA8 grouped by SOX8-low versus SOX8-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX8→partner) and Y-score (partner→SOX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFNA8 →	+0.052	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2W1 →	+0.023	+5.977	<.001	.001	3	1
LUNG_NSCLC_LUAD	GPHA2 →	+0.341	+3.628	<.001	.006	3	1
LUNG_NSCLC_LUAD	TPRX1 →	+0.012	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	SSTR3 →	+0.028	+3.825	<.001	.006	3	1
BLOOD_Lymphoma	MS4A10 →	+0.006	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 237 associations by consensus.

IFNA8 by SOX8 expression — SOFT_TISSUE

Explore this box plot interactively →